Pharmaceutics
Tablet Disintegration & Dissolution Profile Plotter
Plots a tablet's disintegration and dissolution over time and reads off Td, T₅₀, T₉₀ and the USP Q = 80% check.
T₅₀ dissolution
13.6min
Meets Q = 80% — 98.0% dissolved at 30 min
Key parameters
Updated live as you edit the data.
Profile data
Time in minutes; disintegration and dissolution in % (0–100).
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Add a time point
Sampling time
Share of tablet broken up
Drug dissolved, % of label claim
| Time (min) | Disint. (%) | Dissol. (%) | Remove |
|---|---|---|---|
| 0 | 0% | 0% | |
| 5 | 15% | 5% | |
| 10 | 65% | 25% | |
| 15 | 100% | 60% | |
| 20 | 100% | 85% | |
| 30 | 100% | 98% |
Profile plot
Dashed lines mark 50% and the Q = 80% acceptance level.
Working
Linear interpolation between the points either side of each threshold.
t = 10 + (100 − 65) ÷ (100 − 65) × (15 − 10)
t = 5 + (50 − 15) ÷ (65 − 15) × (10 − 5)
t = 10 + (50 − 25) ÷ (60 − 25) × (15 − 10)
t = 20 + (90 − 85) ÷ (98 − 85) × (30 − 20)
Dissolution requirements by dosage form
| Dosage form | Apparatus | Speed (rpm) | Medium | Q value | Time point |
|---|---|---|---|---|---|
| Immediate Release | I or II | 50-100 | 0.1N HCl, buffer | 75-80% | 30-45 min |
| Extended Release | I or II | 50-100 | Multiple pH | Varies | Multiple |
| Enteric Coated | I or II | 50-100 | Acid then buffer | 75% (buffer) | 45-120 min |
| Orally Disintegrating | USP <701> | N/A | Water | N/A | ≤30 sec |
Source: USP <701>, <711>; FDA guidance.
t = t₁ + (X − y₁) ÷ (y₂ − y₁) × (t₂ − t₁)
X is the threshold (50% for T₅₀, 90% for T₉₀, 100% for disintegration time Td). (t₂, y₂) is the first point at or above X and (t₁, y₁) the point before it. If the very first point already meets X, its time is used.
Q check: % dissolved at the 30-min point ≥ 80%
Profile similarity between a test (T) and reference (R) product uses the f₂ factor:
f₂ = 50·log{[1 + (1/n)Σ(Rᵢ − Tᵢ)²]⁻⁰·⁵ × 100}
f₂ ≥ 50 indicates similarity. If ≥ 85% is dissolved in 15 min, profiles are considered similar without f₂.
Keep learning
References
- United States Pharmacopeia–National Formulary. General Chapter <711> Dissolution. Rockville (MD): USP.
- U.S. Food and Drug Administration. Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms. Rockville (MD): FDA; August 1997.
- Moore JW, Flanner HH. Mathematical comparison of dissolution profiles. Pharm Technol. 1996;20(6):64–74.
Common questions
Disintegration is the tablet breaking into particles (USP <701>); dissolution is the drug going into solution (USP <711>). A tablet can disintegrate quickly and still dissolve slowly, which is why both curves are plotted.
The check looks for a sampling time of exactly 30 minutes and uses the measured value there — it does not interpolate. Add a 30-min time point to see it.
None of your points reaches 90% dissolved, so there is nothing to interpolate to. Extend the sampling time or check that percentages are of label claim.
No. Points are sorted by time as they are added, and every interpolated time is taken from neighbouring rows in that sorted order.
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