Clearance (CL) Calculator

Dose / AUC or Infusion rate / Css

Elimination capacity

Calculation Method

Dose (mg)

AUC (mg·h/L)

Volume of Distribution (L) – optional

Enter to calculate half‑life: t½ = 0.693·Vd/CL

Example Drugs

Formulae

CL = Dose / AUC (single dose)

CL = R₀ / Css (steady‑state)

t½ = 0.693 × Vd / CL

Clearance Scale

<0.5 L/hSevere impairment

0.5–2 L/hReduced

2–10 L/hNormal

10–30 L/hHigh

>30 L/hFlow‑limited