Antagonism Simulator

Model receptor‑antagonist interactions

Pharmacodynamics

Antagonism Parameters

Agonist [A] (µM)

Antagonist [B] (µM)

Agonist affinity kₐ (µM⁻¹)

Antagonist affinity k_b (µM⁻¹)

Maximal Response Emax (%)

Predicted Effect

Enter values

Competitive antagonist shifts curve right without affecting maximum. Higher agonist dose can overcome blockade. [citation:1][citation:6]

log(DR - 1) = log[B] - log K_B

DR = dose ratio; slope = 1 for competitive antagonism [citation:6]