Accumulation Index Calculator
Predict drug accumulation with repeated dosing
Multiple Dosing
Dosing Parameters
Formula: Accumulation index R = 1 / (1 – e-k·τ), where k = 0.693 / t½ [citation:6]
Results
Accumulation Index (R)
—
Elimination rate constant (k)
— hours⁻¹
Steady state reached
—%
after 4 half‑lives
Clinical Implications
Per systematic review of 122 studies [citation:6]
Accumulation Scale
R < 1.2 No to weak
1.2 ≤ R < 2 Weak
2 ≤ R < 5 Moderate
R ≥ 5 Strong