Therapeutic Index Calculator
TI = TD₅₀ / ED₅₀ – safety margin
Enter Doses
Dose effective in 50% of population
Example Drugs
TI Safety Guidelines
| TI Range | Classification | Monitoring |
|---|---|---|
| TI < 2 | Very Narrow | Continuous TDM required |
| TI 2–5 | Narrow | Regular TDM recommended |
| TI 5–10 | Moderate | Routine monitoring |
| TI > 10 | Wide | Minimal monitoring |
Note
TI derived from quantal dose‑response curves in animals [citation:4][citation:9]. For humans, therapeutic window based on population data.