Kinetics Calculator
First‑order, zero‑order & Michaelis‑Menten elimination models
Elimination Models
Model Selection
Rate proportional to concentration – constant half‑life
Initial Conditions
Examples
Results
Clinical Implications
- • First‑order: Safe, predictable elimination; dose proportional [citation:7]
- • Zero‑order: Risk of accumulation at high doses; small dose changes can cause large concentration swings [citation:7]
- • Mixed kinetics: Requires therapeutic drug monitoring (phenytoin, theophylline)
Model Comparison
ParameterFirst-OrderZero-Order
Ratek·CV_max
Half-lifeConstantVariable
ExamplesMost drugsEthanol, Aspirin (high dose)