Drug-Excipient Compatibility Predictor
Risk assessment for chemical interactions
Chemical Properties
Drug Functional Groups
Excipient Types
Environmental Factors
Common Interactions
Maillard Reaction
Primary amines + Reducing sugars → brown discoloration.
Ester Hydrolysis
Esters degrade in high pH/moisture.
Oxidation
Phenols/thiols oxidize with metal ions/O₂.
Testing Strategy
Binary mixtures (drug + each excipient).
Accelerated conditions (40°C/75% RH).
Monitor: color, assay, degradation products.
Use DSC, FTIR, HPLC.
High-Risk Combinations
Amino drugs + Lactose
Aspirin + Alkaline excipients
Antioxidants + Oxidizing agents
Formulation Tips
For amine drugs: Use mannitol instead of lactose.
For ester drugs: Maintain acidic pH, use desiccants.
For oxidation-prone: Add antioxidants, nitrogen blanket.